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    The live attenuated vaccine containing strain Yersinia pestis EV is used for plague immunization.

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    Even if the host does develop antibodies, protection might not be adequate; immunity might develop too slowly to be effective in time, the antibodies might not disable the pathogen completely, or there might be multiple strains of the pathogen, not all of which are equally susceptible to the immune reaction.The valency of a multivalent vaccine may be denoted with a Greek or Latin prefix (e.g., tetravalent or quadrivalent).In certain cases, a monovalent vaccine may be preferable for rapidly developing a strong immune response.Examples include the viral diseases yellow fever, measles, mumps, and rubella, and the bacterial disease typhoid.The live Mycobacterium tuberculosis vaccine developed by Calmette and Guérin is not made of a contagious strain but contains a virulently modified strain called "BCG" used to elicit an immune response to the vaccine.

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